acute myeloid leukemia t[18;21][q22;q22];(AML1/ETO)

Epidemiology: ~5-12% of AML cases Pathology: - generally showing maturation in neutrophil lineage - myeloid sarcomas may be present - CD56 expression & other karyotypic abnormalities may be associated with poorer prognosis Genetics: - chromosomal translocation involving AML1 & ETO genes Management: - usually associated with good response to chemotherapy, complete remission & long term disease free survival when treated with high dose cytarabine in consolidation phase

References

WHO Classification Tumours of Haematopoietic and Lymphoid Tissues. IARC Press 2001